Detection of BTNL2 Gene Mutation (rs2076530 Allele) in Iranian Sarcoidosis Patients: A clinical and Genetic Study
نویسندگان
چکیده
منابع مشابه
Polymorphism of rs2076530 allele in BTNL2 gene in patients with skin sarcoidosis compared to skin sarcoidal reaction and normal skin: A case-control study
Background: In 10-30% of the cases with sarcoidosis, skin lesions appear solely without any systemic signs or symptoms. BTNL2 gene, which is a member of the immunoglobulin gene super family and is associated with CD86 and CD80 co-stimulatory receptors, is identified to play an important role in the establishment of sarcoidosis. We aimed to evaluate the role of this gene in patients with skin sa...
متن کاملبررسی جهش ژن BTNL2 در بیماران مبتلا به سارکوئیدوز پوستی
Background and Aim: Sarcoidosis is a non-caseous granulomatous disease that can involve several organs such as lung, kidney, liver, heart and skin. In systemic sarcoidosis, skin lesions occur in 20-35% of patients. Cutaneous sarcoidosis with no systemic involvement was found in about 25% of patients. Mutation within Butyrophilin-like 2 (BTNL2) gene, rs2076530 was reported in systemic sarcoidosi...
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Is there a genetic predisposition for Turkish patients with sarcoidosis in the 329-bp region containing the BTNL2 rs2076530 polymorphism?
BACKGROUND/AIM Sarcoidosis is a complex, multifactorial immune disorder with unknown etiology. A single nucleotide polymorphism (G→A, rs2076530) in the butyrophilin-like 2 (BTNL2) gene results in a truncating protein formation. It has been previously reported that this variation may be a risk factor for sarcoidosis in certain ethnic groups. This study was conducted to determine whether there is...
متن کاملBTNL2 gene variant and sarcoidosis.
is a safe test when performed in experienced centres. Indeed, a review of .6500 ITTs reported that only seven patients (0.1%) experienced an adverse event, all of which reversed following intravenous glucose. To our knowledge, only two studies have used the ITT to investigate the HPA axis in asthmatic children treated with inhaled fluticasone. The first reported an inadequate response to insuli...
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ژورنال
عنوان ژورنال: Internal Medicine: Open Access
سال: 2017
ISSN: 2165-8048
DOI: 10.4172/2165-8048.1000239